Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice
COPD subjects show increased airway epithelial senescence, and these cells can be cleared therapeutically using the senolytic cocktail of D + Q, reducing broad-spectrum pulmonary inflammation <i>in vitro</i> and <i>in vivo</i>.
Authors
- Yasuo Kizawa (ORCID: https://orcid.org/0000-0001-9884-7186)
- Shyreen Hassibi (ORCID: https://orcid.org/0000-0003-1694-4594)
- Kazuhiro Ito (ORCID: https://orcid.org/0000-0001-9320-2717)
- Leah Daly
- Genki Kimura (ORCID: https://orcid.org/0009-0004-9616-7821)
- Yuki Nishimoto
- Jonathan Baker
Institutions
- Nihon University (JP)
- Imperial College London (GB)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fmed.2025.1451056
- Citations
- 5
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 8.13