Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway
Our study demonstrates that irisin ameliorates cardiac function and enhances early prognosis in HS. These cardioprotective effects are achieved through attenuation of myocardial damage and SIRT1/AMPK/Drp1 pathway-dependent restoration of mitochondrial homeostasis.
Authors
- Yunfei Chi (ORCID: https://orcid.org/0000-0002-2997-6555)
- Xiaofang Zou (ORCID: https://orcid.org/0000-0003-1287-6192)
- Quanxi Zhang (ORCID: https://orcid.org/0000-0002-0124-1872)
- Hongjie Duan
- Bin Wei (ORCID: https://orcid.org/0000-0001-9074-9098)
- Jiake Li (ORCID: https://orcid.org/0000-0002-3867-1841)
- Hailiang Bai (ORCID: https://orcid.org/0000-0002-7983-1290)
- Haiyan Liu (ORCID: https://orcid.org/0009-0002-1452-6743)
- Zheng Zhang (ORCID: https://orcid.org/0000-0001-8433-1568)
- Weihua Cao
- Yufang Zhang (ORCID: https://orcid.org/0009-0009-3422-0224)
- Huiting Yun
Institutions
- Shanxi Medical University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fphar.2025.1560608
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33