Primary Percutaneous Coronary Intervention and Left Ventricular Function Recovery in Acute Myocardial Infarction

Objective: Primary percutaneous coronary intervention (PCI) has emerged as the gold standard for the management of ST-segment elevation myocardial infarction (STEMI), significantly improving patient outcomes. The objective of this study was to assess the impact of primary PCI on left ventricular function recovery in Acute MI patients. Methodology: A retrospective study was conducted at the Department of Cardiology, Hayatabad Medical Complex, Peshawar, from July 2017 to June 2018. A total of 300 patients (mean age: 61.1 ± 13.32 years; 60% male, 40% female) were included. Pre-PCI and post-PCI Left Ventricular Ejection Fraction (LVEF) were analyzed, along with the incidence of microvascular obstruction (MVO) and major adverse cardiovascular events (MACE). Statistical analysis was performed using paired t-tests and chi-square tests, with significance set at p<0.05. Results: The mean pre-PCI LVEF was 48.47% (± 7.99), increasing to 49.14% (± 8.51) at follow-up (p = 0.2524). MVO was present in 56.33% of patients, while 49% experienced MACE. Gender differences in MACE incidence (male: 52%, female: 46%) were not statistically significant (p >0.05). Conclusion: PCI alone did not significantly improve LVEF, indicating the need for additional therapeutic strategies. High rates of MVO and MACE highlight the necessity for comprehensive post-PCI management to enhance cardiac recovery. Keywords: Left ventricular function, MACE, Microvascular Obstruction, Myocardial infarction,