Donor adipose-derived stromal cells are vasoprotectant but unable to revert acute rejection in rodent vascularized composite allotransplants
Although systemic and local ASC therapy reduces progression of acute rejection in vascularized composite allotransplantation, it is not able to revert rejection without additional immunosuppressive therapy. However, graft vasculitis during acute rejection is significantly reduced after cytotherapy.
Authors
- Souzan Salemi (ORCID: https://orcid.org/0000-0002-9777-3717)
- Matthias Waldner (ORCID: https://orcid.org/0000-0002-7123-4205)
- Holger J. Klein (ORCID: https://orcid.org/0000-0003-4129-4634)
- Fabienne Lehner (ORCID: https://orcid.org/0000-0002-5817-2249)
- Adriano Taddeo (ORCID: https://orcid.org/0000-0003-3281-1548)
- Branislav Kollár (ORCID: https://orcid.org/0000-0001-6668-7798)
- Pranitha Kamat (ORCID: https://orcid.org/0000-0002-9177-3513)
- Daniel Eberli (ORCID: https://orcid.org/0000-0001-8866-8010)
- Jan A. Plock (ORCID: https://orcid.org/0000-0002-9495-6198)
- Peter K. Bode (ORCID: https://orcid.org/0000-0002-9633-4042)
- Riccardo Schweizer (ORCID: https://orcid.org/0000-0002-5686-8496)
- Klara Stölzl
Institutions
- University of Freiburg (DE)
- University of Lucerne (CH)
- University of Zurich (CH)
- University Hospital of Bern (CH)
- University Medical Center Freiburg (DE)
- University Hospital of Zurich (CH)
- Kantonsspital Aarau (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fimmu.2025.1581599
- Citations
- 1
- Primary Topic
- Organ and Tissue Transplantation Research
- Type
- article
- Field-Weighted Citation Impact
- 1.99
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Hartmann Müller-Stiftung für Medizinische Forschung