Colpomenia sinuosa extract mitigates lead acetate-induced testicular dysfunctions in male rats
This study for the first time investigated the biochemical and molecular mechanisms regarding the effects of CSE treatment on PbAc-induced testicular damage in male rats. CSE showed potential attenuative effect on the testis injury induced by PbAc treatment by targeting JAK2/STAT3, and NLRP3/Caspase-1 pathways. These findings suggest that CSE could be used against the adverse effect of PbAc on male repro-toxicity.
Authors
- Thamir M. Eid (ORCID: https://orcid.org/0000-0001-9513-8202)
- Maysa A. Mobasher (ORCID: https://orcid.org/0000-0003-2987-0387)
- Hayat M. Albishi
- Fahad Abdullah Alshanbari (ORCID: https://orcid.org/0000-0001-7267-4301)
- Noorah Saleh Al‐Sowayan (ORCID: https://orcid.org/0000-0003-1631-6467)
- Layla A. Almutairi (ORCID: https://orcid.org/0000-0001-8189-6512)
- Karim Samy El-Said (ORCID: https://orcid.org/0000-0003-1511-6033)
- Sahar Abdulrahman Alkhodair
- Najlaa Yousef Abuzinadah
- Amal S. Abu-Almakarem
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Qassim University (SA)
- King Abdulaziz University (SA)
- Jouf University (SA)
- Tanta University (EG)
- University of Jeddah (SA)
- Al Baha University (SA)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fmolb.2025.1551773
- Citations
- 1
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 1.20