Follow-up of hereditary endometrial carcinoma caused by MLH3 gene mutation: a case report
This case identifies germline heterozygous mutations in two patients, suggesting a potential role for <i>MLH3</i> in endometrial carcinogenesis, which may act as a low-risk factor to increase the risk of tumor susceptibility and does not rule out the possibility of synergistic increases in pathogenicity with other genes.
Authors
- Qiaqia Li (ORCID: https://orcid.org/0000-0002-5052-3331)
- Jundong Li (ORCID: https://orcid.org/0000-0002-1878-817X)
- Li Tian (ORCID: https://orcid.org/0000-0001-7359-7571)
- Jiaying Ye
- Jijie Zhan (ORCID: https://orcid.org/0009-0008-6433-3871)
- Yang Dong (ORCID: https://orcid.org/0000-0001-7789-8945)
- Changlin Zhang (ORCID: https://orcid.org/0000-0001-7242-7378)
- Ting Wan (ORCID: https://orcid.org/0000-0002-6229-4441)
Institutions
- Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fonc.2025.1532908
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Jinan University
- State Key Laboratory of Oncology in South China
- Basic and Applied Basic Research Foundation of Guangdong Province