Protective effect of antidiabetic drugs against male infertility: evidence from Mendelian randomization
Our study indicates that metformin, SGLT2i, insulin and its analogs, as well as sulfonylureas, may offer potential therapeutic benefits for MIF. Specifically, six antidiabetic drug target genes GPD1, SLC5A1, IGF1R, TRPM4, CPT1 A, and CPE may play a role in the progression of MIF. These findings have significant implications for the development of personalized precision therapies for MIF.
Authors
- Qingfu Deng (ORCID: https://orcid.org/0009-0008-4836-9495)
- Chunyang Meng
- Tao Zhou (ORCID: https://orcid.org/0000-0002-9265-4946)
- Zhiyu Liu (ORCID: https://orcid.org/0009-0004-0351-7213)
- Xinyao Zhu
- Qilong Wu
- Yuqi Li (ORCID: https://orcid.org/0009-0000-5662-2640)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1186/s13098-025-01700-0
- Citations
- 5
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 8.49
Funders
- Southwest Medical University
- Luzhou Science and Technology Bureau