Deciphering ERR family genes as prognostic and immunological biomarkers through pan-cancer analysis with validation in gallbladder cancer
Our pan-cancer analysis reveals ERRs as critical regulators of tumor immunity and progression, with ESRRG emerging as a key oncogenic driver in GBC. The mechanistic link between ESRRG and PD-L1/EMT suggests its potential as a therapeutic target to enhance immunotherapy efficacy. These findings underscore the need for tissue-specific targeting strategies for ERR family members in precision oncology.
Authors
- Xingmei Guo (ORCID: https://orcid.org/0000-0003-4517-9676)
- Hui Zhao (ORCID: https://orcid.org/0000-0001-5491-1633)
- Meiqin Li
- Fan Wu (ORCID: https://orcid.org/0000-0003-3615-1217)
- Daozhen Chen (ORCID: https://orcid.org/0000-0003-4791-8065)
- Yu Chen (ORCID: https://orcid.org/0000-0002-5765-6209)
- Lei Wang (ORCID: https://orcid.org/0000-0002-3368-2832)
- Mengmeng Yang (ORCID: https://orcid.org/0000-0003-0681-4630)
- Ping Sun (ORCID: https://orcid.org/0000-0002-6572-307X)
- Wanwan Gong
- Sijia Wen
Institutions
- Jiangnan University (CN)
- Jiangsu Institute of Parasitic Diseases (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fonc.2025.1525635
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00