MS4A7 based metabolic gene signature as a prognostic predictor in lung adenocarcinoma
The MS4A7 gene plays a critical role in LUAD prognosis, particularly through its involvement in immune modulation within the TME. MS4A7<sup>+</sup> macrophages, characterized by distinct metabolic reprogramming and immune interactions, are pivotal in shaping LUAD progression and immune response. The findings highlight the potential of MS4A7 as a novel prognostic biomarker and therapeutic target for LUAD. Further investigation into the metabolic and immune regulatory mechanisms of MS4A7<sup>+</sup> macrophages could offer new insights into LUAD treatment strategies.
Authors
- Liwen Fu
- Weicheng Zeng
- Zhengyu Shu (ORCID: https://orcid.org/0000-0002-4528-8306)
- Taiping He (ORCID: https://orcid.org/0000-0001-6213-0837)
- Yanfeng Jiang (ORCID: https://orcid.org/0000-0002-5006-5190)
- Lei Cheng (ORCID: https://orcid.org/0000-0002-2762-4740)
- Xuefei Li (ORCID: https://orcid.org/0000-0002-4119-4652)
- Chao Zhao (ORCID: https://orcid.org/0000-0003-1739-1151)
- Haowei Wang (ORCID: https://orcid.org/0009-0004-1186-4303)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Shanghai Pulmonary Hospital (CN)
- Shanghai First People's Hospital (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-04-28
- DOI
- https://doi.org/10.3389/fmolb.2025.1591446
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61