Effect of Left Ventricular Hypertrophy on Left Ventricular Global Longitudinal Strain in Patients Undergoing Primary Percutaneous Coronary Intervention

Background: Left ventricular (LV) global longitudinal strain (GLS) has recently garnered attention as a reliable and objective method for evaluating LV systolic function, so we want to study the causal relationship between them and that by detecting the effect of LVH on cardiac function measured by Global Longitudinal Strain (GLS) in patients undergoing primary PCI and to fill existing gaps in the literature, particularly regarding GLS and its clinical relevance in LVH populations. Methods: This prospective cohort study was carried out at Zagazig university hospital, cardiology department (coronary care unit) from August 2021 to August 2023 and included 110 acute STEMI Patients that were subjected to PPCI They were devided into two groups: Group 1; 55 patients STEMI patients without (LVH). Group 2; 55 patients STEMI patients with (LVH). Results: The LVH group had statistically significant higher systolic, diastolic BP, and peak troponin levels than the non-LVH group (P<0.001). The LVH group had statistically significant higher mean LA, LV mass index, IVST, PWT, RWT, and RWMSI (P<0.05) than the non-LVH group at hospital stay and after six months, but statistically significant lower LVEDV, LVESV, and EF. GLS at hospital stay can statistically significantly predict the incidence of 6-months MACE in LVH group at cut off >-7.2, with 75.0% sensitivity, 89.74% specificity, 75% PPV and 89.7% NPV. Conclusion: GLS and peak troponin can be used as predictors of 6-month MACEs. GLS is a readily available, unexpensive method for detection the impact of LVH on STEMI patients.