Correlations of Dermoscopic Features with Histopathological Features in Common Benign Facial Skin Lesions in Adults

Background: Correspondence of histopathological findings with dermoscopic patterns and colors has been reported for numerous skin lesions. Also, correspondence of dermoscopic and histopathological features with age groups, certain body sites and pigmentary traits has been investigated. Aim of work: This study aims to correlate dermoscopic characteristics of common benign facial skin lesions with clinical and Histopathological features. Patients & Methods: This study included 113 studied cases with clinical & dermoscopic benign facial skin lesions. Clinical data had been collected from comprehensive databases including patient age, sex, and affected sites. Dermoscopic images were reviewed by a member of the International Society of Dermoscopy. Histological classification of excisional biopsies was based on hematoxylin-eosin stained slides. Results: Comparing to pathology as a gold standard technique dermoscopy showed perfect performance characteristics regarding Sebaceous Hyperplasia and Angiofibroma. The dermoscopy had sensitivity of 96.4% for detection of nevi, with specificity of 98.2%, positive predictive value of 98.2% and negative predictive value of 96.6% with high accuracy of 97.3%. The dermoscopy had sensitivity of 93.6% for detection of SK with specificity of 98.5%, positive predictive value of 97.8% and negative predictive value of 95.6% with high accuracy of 96.5%. Performance characteristics ranged from 93.6% up to 100% in all lesions except for BCC (one case which showed no malignant clinical or dermoscopic features). Conclusion: Histopathology & dermoscopy have a good agreement. So, dermoscopy can be used as a routine diagnostic tool during dermatological examinations. However, non or slightly-pigmented skin lesions could be misdiagnosed with dermoscopy as benign lesions but pathologically it is malignant, so histopathology is still the cornerstone for diagnosing or confirming the diagnosis of most cutaneous disorders.