Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions
miRs may inhibit mRNA vaccine translation in APCs, potentially reducing antigen production and weakening the resulting immune response. To address this, next-generation mRNA vaccines should incorporate "miR-proofing" strategies during design to avoid miR interference.
Authors
- Muhammad Irfan (ORCID: https://orcid.org/0000-0003-4161-6875)
- Bin Zheng (ORCID: https://orcid.org/0000-0002-7682-6648)
- Tielong Xu (ORCID: https://orcid.org/0000-0001-9432-9584)
- Anindini Winda Amalia (ORCID: https://orcid.org/0000-0003-4868-0183)
- Yicheng Yu
- Ziqi Lin (ORCID: https://orcid.org/0009-0000-2154-8014)
- Munir Ahmed
- Maya Septriana
- Twinky Zebrina Cysta Sumantri
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Universitas Airlangga (ID)
- Institut Ilmu Kesehatan Bhakti Wiyata (ID)
Publication Details
- Journal
- Infectious Diseases of Poverty
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1186/s40249-025-01308-6
- Citations
- 1
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China