HMGB1 Modulates Angiogenic Imbalance and Cardiovascular Complications in Preeclampsia through Decorin and VEGF Regulation
Our findings indicate that HMGB1 plays a critical role in preeclampsia by mediating the upregulation of anti-angiogenic factors like Decorin and the downregulation of angiogenic factors like VEGF. This study highlights a significant correlation between HMGB1 and Decorin in driving the angiogenic imbalance that contributes to the pathophysiology of PE.
Authors
- Huma Quasimi
- Gausal A. Khan (ORCID: https://orcid.org/0000-0002-0306-6641)
- Sheema Wazib
- Iqbal Alam (ORCID: https://orcid.org/0000-0002-3285-7282)
Institutions
- Jamia Hamdard (IN)
- King Faisal University (SA)
Publication Details
- Journal
- Reports of Biochemistry and Molecular Biology
- Published
- 2024-11-01
- DOI
- https://doi.org/10.61186/rbmb.13.3.385
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Council of Medical Research