Development and validation of a genetic probability for venous thromboembolism
GenProb-VTE, an optimized tool combining PGS with FVL/PGM, significantly improves VTE risk assessment compared with FVL/PGM alone in diverse ancestry populations. It provides a novel tool for genetic risk assessment of VTE.
Authors
- Arman Qamar (ORCID: https://orcid.org/0000-0003-0607-1240)
- Alan R. Sanders (ORCID: https://orcid.org/0000-0001-6629-4011)
- Clay Wiske (ORCID: https://orcid.org/0000-0001-9251-0080)
- Jianfeng Xu (ORCID: https://orcid.org/0000-0002-1343-8752)
- Michal Filipczak
- Zhuqing Shi (ORCID: https://orcid.org/0000-0001-6321-950X)
- Andrew S. Rifkin (ORCID: https://orcid.org/0009-0004-9038-7014)
- Alfonso Tafur
- David Duggan
- Jeffrey S. Lobel
- Van Huy Tran (ORCID: https://orcid.org/0000-0002-2155-2555)
- Ashley J. Mulford
- Song Gao (ORCID: https://orcid.org/0000-0002-0644-2585)
- Jun Wei (ORCID: https://orcid.org/0000-0001-6002-3413)
- Brian T. Helfand (ORCID: https://orcid.org/0000-0002-7707-3318)
- Annabelle Ashworth
- Siqun L. Zheng
- Shuhua Xie (ORCID: https://orcid.org/0009-0002-8500-2023)
Institutions
- Translational Genomics Research Institute (US)
- NorthShore University HealthSystem (US)
- University of Chicago (US)
- Center for Genomic Science (IT)
- Stanford University (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1016/j.rpth.2025.102876
- Citations
- 1
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.87