Identification of molecular subtypes and a prognostic risk model based on mitochondrial dynamic related genes in clear cell renal cell carcinoma
Our findings advance the understanding of mitochondrial dynamics in ccRCC progression, demonstrating that PINK1-mediated enhancement of mitophagy critically potentiates the anti-tumor effects of sunitinib in ccRCC.
Authors
- Zitong Lei (ORCID: https://orcid.org/0000-0001-8621-5309)
- Kaibo Yang (ORCID: https://orcid.org/0009-0002-7707-0288)
- Chang Liu (ORCID: https://orcid.org/0009-0007-3808-1466)
- Kunjin Wu (ORCID: https://orcid.org/0000-0002-4870-3536)
- Kai Qu (ORCID: https://orcid.org/0000-0002-9331-5241)
- Jing Li (ORCID: https://orcid.org/0000-0001-7538-246X)
- Qiuting Peng
- Kun Yang
- Ting Lin
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1016/j.bbrc.2025.151911
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Fund for Distinguished Young Scholars