Metamizole induces voriconazole metabolism and results in subtherapeutic voriconazole concentrations
Metamizole increases voriconazole metabolism and decreases voriconazole trough concentrations, probably through a CYP3A4 and CYP2C19 inducing effect. It is recommended to avoid concurrent use of metamizole and voriconazole or to closely monitor voriconazole trough concentrations during metamizole treatment and up to 2 weeks after discontinuation of metamizole.
Authors
- Daan J. Touw (ORCID: https://orcid.org/0000-0002-1429-4789)
- Thijs H. Oude Munnink (ORCID: https://orcid.org/0000-0001-8392-5858)
- Marjolijn N. Lub‐de Hooge (ORCID: https://orcid.org/0000-0002-5390-2791)
- Simone D. Baan
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1002/bcp.70079
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00