Population pharmacokinetic analysis of the interaction of digoxin with N‐desethylamiodarone in patients with atrial fibrillation and heart failure
This study revealed that renal impairment and high plasma N-desethylamiodarone concentrations reduce digoxin clearance in patients with atrial fibrillation and heart failure.
Authors
- Toshinori Hirai (ORCID: https://orcid.org/0000-0002-3898-2068)
- Hidefumi Kasai (ORCID: https://orcid.org/0000-0001-5231-8027)
- Tsuyoshi Shiga (ORCID: https://orcid.org/0000-0003-0358-7196)
Institutions
- Jikei University School of Medicine (JP)
- Keio University (JP)
- Tokyo Women's Medical University (JP)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1002/bcp.70075
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39