CCNE1 Promotes the Progression of Hepatic Precancerous Lesion and the Malignant Phenotype of Hepatocellular Carcinoma
CCNE1 promotes HPC progression and HCC cell proliferation, migration, invasion, and survival by activating the PI3K/Akt signaling pathway. Furthermore, CCNE1 enhances the secretion of CCL2 and CCL5 by HCC cells, promoting TAM infiltration and M2 polarization, thereby contributing to tumor progression.
Authors
- Wenzhi Guo (ORCID: https://orcid.org/0000-0002-0821-1318)
- Lichao Yao (ORCID: https://orcid.org/0000-0002-7292-0098)
- Kai Zhang (ORCID: https://orcid.org/0000-0002-8956-6187)
- Xue Hu (ORCID: https://orcid.org/0000-0002-4974-6730)
Institutions
- Wuhan University (CN)
- Chengdu Military General Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2025-04-28
- DOI
- https://doi.org/10.14218/jcth.2024.00428
- Citations
- 2
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 1.61