Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis
This study supported that increased HMGCR expression was associated with an increased risk of cystic kidney disease and PKD, suggesting potential benefits of statin therapy for cystic kidney disease and PKD. Further research is necessary to elucidate specific mechanisms and potential therapeutic applications of HMGCR inhibitors.
Authors
- Zijie Liang (ORCID: https://orcid.org/0000-0001-5115-223X)
- Chao Xie (ORCID: https://orcid.org/0000-0001-9489-5519)
- Zhiwen Lian
- Qiyan Chen (ORCID: https://orcid.org/0000-0001-9072-2135)
- Yaozhong Kong (ORCID: https://orcid.org/0000-0002-9178-6023)
Institutions
- First People's Hospital of Foshan (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1080/0886022x.2025.2491657
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province