CLINICAL AND PARACLINICAL CHARACTERISTICS OF DENGUE HEMORRHAGIC FEVER DURING PREGNANCY AT MILITARY HOSPITAL 103 IN 2023

Objectives: To describe clinical and paraclinical characteristics of Dengue hemorrhagic fever (DHF) during pregnancy at the Department of Infectious Diseases, Military Hospital 103 in 2023. Methods: A cross-sectional descriptive study was conducted on 162 pregnant patients diagnosed with DHF and treated at the Department of Infectious Diseases during the 2023 epidemic (from January 2023 to December 2023). Results: The average age was 28.92 ± 5.64 years old, and the average gestational age was 18.98 ± 16.75 weeks. Clinical characteristics: Fever was 84.4%; headache and eye socket pain was 76.5%; bleeding gums was 8.6% and abnormal vaginal bleeding was 2.5%; pleural or peritoneal effusion was 7.4%. Paraclinical characteristics: Decreased white blood cell (WBC) (< 4 G/L) was 28.4%, decreased platelet (< 150 G/L) was 69.1%. The first-trimester group had the highest average hematocrit (HCT) (%) and WBC (p < 0.05), and the second-trimester group had the lowest average platelet (p < 0.05) compared to other groups. Blood biochemistry tests showed increased AST (≥ 40 U/L) and ALT (≥ 40 U/L) in 46.7% and 49.3% of cases, respectively. The third-trimester group had the highest average AST and ALT compared to other groups (p < 0.01). Disease severity was classified as DHF with warning signs in 24.7% of cases and severe DHF in 1.8% of cases. The third-trimester group had the highest rate of DHF with warning signs and severe DHF (p < 0.05). Conclusion: Pregnant women with DHF exhibit different clinical and paraclinical characteristics depending on the stage of pregnancy. The third-trimester group experienced more severe liver injury and disease severity compared to the first and second-trimester groups.