RESEARCH ON CHANGES IN SOME CHARACTERISTICS OF ACTIVATED UMBILICAL CORD BLOOD PLATELET-RICH PLASMA AFTER STORAGE AT NORMAL COLD TEMPERATURE

Objectives: To evaluate sensory changes, infection, epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) concentrations in activated umbilical cord blood platelet-rich plasma (PRP) after cold storage at 2 - 6 degrees Celsius (°C). Methods: The study was conducted on 8 umbilical cord blood samples and 8 venous blood samples of adults. Results: EGF concentrations in PRP from umbilical cord blood and adult blood after activation were 115.72 (51.59 - 217.61) pg/mL and 113.04 (69.71 - 155.73) pg/mL (p > 0.05), with VEGF concentration being 193.99 (75.58 - 320.25) pg/mL and 16.12 (11.70 - 49.03) pg/mL, respectively, p < 0.01. After cold storage at 2 - 6°C for 7 days, 10 days, and 14 days, the concentrations of EGF and VEGF in PRP from activated umbilical cord blood showed no difference compared to immediately after activation (p > 0.05). PRP remained clear and yellow, with no signs of infection. Conclusion: PRP from umbilical cord blood has high VEGF concentration, no significant change in appearance, EGF and VEGF concentrations, and sterility after cold storage for 7 - 14 days.