Isavuconazole therapeutic drug monitoring and association with adverse events
Our findings identified an exposure-toxicity relationship for isavuconazole. Therapeutic drug monitoring may be beneficial for those on isavuconazole therapy who develop signs or symptoms of potential toxicity. Additionally, in patients with adverse events attributed to isavuconazole, dose reduction often led to resolution.
Authors
- Derek J. Bays (ORCID: https://orcid.org/0000-0003-0264-5569)
- Melissa J. Chee (ORCID: https://orcid.org/0000-0003-3815-9095)
- Joy Vongspanich Dray
- Elizabeth H. Robison (ORCID: https://orcid.org/0000-0003-1757-7941)
- Emily Huang (ORCID: https://orcid.org/0000-0001-5591-3171)
- Machelle Wilson (ORCID: https://orcid.org/0000-0003-1734-2755)
- Kate Trigg
- Jeffrey Fine (ORCID: https://orcid.org/0000-0002-6396-9383)
- Rebecca Wittenberg
- George R. Thompson (ORCID: https://orcid.org/0000-0001-7093-5379)
Institutions
- University of California Davis Medical Center (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1093/jac/dkaf128
- Citations
- 12
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 16.75
Funders
- Norges Idrettshøgskole
- National Institutes of Health
- National Center for Advancing Translational Sciences