HIV-1 cross-resistance to second-generation non-nucleoside reverse transcriptase inhibitors among individuals failing antiretroviral therapy in Cameroon: implications for the use of long-acting treatment regimens in low- and middle-income countries
Among patients failing treatment in Cameroon, there is a high-level of cross-resistance to 2ndGenNNRTI due to wide exposure to 1stGenNNRTI. Thus, in LMICs sharing similar programmatic features, the use of NNRTI-sparing regimens should be prioritized as a public health approach, while second-generation-NNRTI long-acting regimens should be guided by genotyping or for clients without previous exposure to NNRTIs.
Authors
- Grâce Beloumou (ORCID: https://orcid.org/0000-0002-6870-7366)
- Alex Durand Nka (ORCID: https://orcid.org/0000-0002-9358-8661)
- Ezéchiel Ngoufack Jagni Semengue (ORCID: https://orcid.org/0000-0001-8768-2371)
- Alexis Ndjolo (ORCID: https://orcid.org/0000-0002-4951-9271)
- Nicaise Ndembi (ORCID: https://orcid.org/0000-0001-5131-3136)
- Yagaï Bouba (ORCID: https://orcid.org/0000-0002-4187-683X)
- Sandrine Djupsa
- Joseph Fokam (ORCID: https://orcid.org/0000-0002-1501-2763)
- Collins Ambe Chenwi (ORCID: https://orcid.org/0000-0002-6749-1436)
- Vittorio Colizzi (ORCID: https://orcid.org/0000-0003-0007-8580)
- Aude Christelle Ka’e (ORCID: https://orcid.org/0000-0002-2381-4299)
- Carlo Federico Perno (ORCID: https://orcid.org/0000-0002-0825-5388)
- Davy-Hyacinthe Gouissi Anguechia
- Désiré Takou
- Dora Mbanya
- Vincent Kamaël Mekel
Institutions
- University of Rome Tor Vergata (IT)
- University of Maryland, Baltimore (US)
- Université de Yaoundé I (CM)
- University of Buea (CM)
- University of Health Science (KH)
- Centre International De Reference Chantal Biya (CM)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Africa Centres for Disease Control and Prevention (ET)
- Bambino Gesù Children's Hospital (IT)
- Ministry of Public Health (CM)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1093/jacamr/dlaf059
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00