Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and Their Relationship With Molecular Pathology and Disease Outcomes
Patients with early untreated RA showed divergent immune cell signatures between synovia and PB. Tph cells, in both compartments, emerged as key markers for inflammation, disease activity, and treatment response.
Authors
- Katriona Goldmann (ORCID: https://orcid.org/0000-0002-9073-6323)
- Alessandra Nerviani (ORCID: https://orcid.org/0000-0003-4064-4014)
- R. A. Moura (ORCID: https://orcid.org/0000-0002-9685-6924)
- Liliane Fossati‐Jimack (ORCID: https://orcid.org/0000-0003-3757-3999)
- Vasco C. Romão (ORCID: https://orcid.org/0000-0002-5603-9436)
- Elena Pontarini (ORCID: https://orcid.org/0000-0003-0439-0344)
- Giovanni Giorli (ORCID: https://orcid.org/0000-0002-8248-2298)
- Felice Rivellese (ORCID: https://orcid.org/0000-0002-6759-7521)
- João Eurico Fonseca (ORCID: https://orcid.org/0000-0003-1432-3671)
- Myles Lewis (ORCID: https://orcid.org/0000-0001-9365-5345)
- Costantino Pitzalis (ORCID: https://orcid.org/0000-0003-1326-5051)
- Cankut Çubuk (ORCID: https://orcid.org/0000-0003-4646-0849)
- Stefano Bombardieri (ORCID: https://orcid.org/0000-0002-3878-5216)
Institutions
- Humanitas University (IT)
- University of Lisbon (PT)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Centro Hospitalar Lisboa Norte (PT)
- Hospital de Santa Maria (PT)
- William Harvey Research Institute (GB)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1002/art.43194
- Citations
- 4
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- National Institute for Health and Care Research
- Versus Arthritis
- Medical Research Council