NRP2+ human mesenchymal stem cells have stemness-associated properties
In contrast to NRP2<sup>-</sup> MSCs, NRP2<sup>+</sup> MSCs exhibited superior proliferation, differentiation abilities, and migration capacity. Moreover, the stimulation of VEGF-C/NRP2 signaling further enhanced the proliferation and differentiation rates, indicating a role of NRP2 in the maintenance of MSC stemness. Hence, NRP2 holds potential as a cell surface marker for identifying beneficial MSCs for regenerative medicine.
Authors
- Ken‐ichi Miyamoto (ORCID: https://orcid.org/0000-0002-1848-2760)
- Kotaro Tanaka (ORCID: https://orcid.org/0000-0002-7743-8778)
- Hiromi Miyauchi
- Takashi L. Suyama (ORCID: https://orcid.org/0000-0002-3595-8126)
- Satoru Miyagi
- Yumi Matsuzaki (ORCID: https://orcid.org/0000-0002-3729-2997)
- Rintaro Yoshikawa
- Yuko Kato (ORCID: https://orcid.org/0000-0002-1748-0720)
Institutions
- Shimane University (JP)
- Fukuoka Tokushukai Hospital (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1186/s41232-025-00376-3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00