TPX2 promotes papillary renal cell carcinoma progression by forming a ceRNA with LINC00894
This study underscores the critical role of TPX2 in type 2 pRCC progression and highlights its potential as a prognostic biomarker and therapeutic target. The TPX2/LINC00894/miR-660-5p regulatory axis provides novel insights into the molecular mechanisms driving pRCC and offers a promising avenue for improving patient prognosis.
Authors
- Ying Zhao (ORCID: https://orcid.org/0000-0003-2415-0911)
- Zhenshan Ding (ORCID: https://orcid.org/0000-0001-8707-9417)
- Wenwei Ying
- Cheng Liu (ORCID: https://orcid.org/0000-0002-4957-0771)
- Lulin Ma
- Ye Yan
Institutions
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- Peking University First Hospital (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-04-28
- DOI
- https://doi.org/10.1186/s12920-025-02120-9
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- National Key Clinical Specialty Discipline Construction Program of China