Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain

Widespread pain in adolescence is linked with poor mental health, pain, and somatic symptoms in childhood. This prospective study in 207 premenarchal adolescents used quantitative sensory testing (QST) and multimodal hypersensitivity (MMH) measures to assess somatosensory system function and identify predictors for widespread pain (≥3/7 sites). We hypothesized that premenarchal pain, somatic symptoms, psychological factors, and somatosensory system function would predict postmenarchal widespread pain, which would be associated with greater menstrual pain intensity. At premenarchal and postmenarchal study visits, participants completed measures of somatic symptoms, a pain body map, psychosocial questionnaires, QST, and experimental MMH measures including auditory, visual, and visceral stimulation. Electroencephalography (EEG) was collected during auditory and visual tasks to identify neural correlates of MMH. Premenarchal widespread pain was reported by 25% of participants, whereas 29% developed new incident widespread pain postmenarche. Adolescents with postmenarchal widespread pain reported greater menstrual pain intensity (median [interquartile range] 47 [28-61]; 0-100 visual analog scale) than those without (24 [8-50], P = 0.001). Elevated somatic symptoms ( P = 0.012), stress ( P = 0.015), and sensitivity to visceral (bladder filling) ( P = 0.046) and unpleasant visual stimuli ( P = 0.043) were significant predictors of postmenarche widespread pain. A multivariable regression model found premenarchal body map score (OR = 1.75, 95% CI [1.20, 2.55]), somatic symptoms (OR = 1.47, 95% CI [1.03, 2.11]), and visual hypersensitivity (OR = 1.62, 95% CI [1.12, 2.33]) predicted postmenarchal widespread pain. No EEG differences in early cortical sensory processing were found. Our results suggest that increased sensitivity to multimodal unpleasant and painful stimuli represents a novel risk factor for postmenarche widespread pain.