Research Progress on the Association Between PU.1 and Liver Fibrosis

Liver fibrosis is a pathophysiological process characterized by excessive proliferation of intrahepatic connective tissue induced by chronic hepatic injury. Its molecular mechanisms include inflammation-mediated macrophage activation, hepatic stellate cell activation, and various fibrogenic pathways. Early fibrosis is reversible, which is why early diagnosis and treatment are essential.The emerging evidence underlines the importance of the transcription factor PU.1 in liver fibrosis development. This review is done to relate PU.1 with liver fibrosis for diagnosis and therapy insight into the condition.翻译搜索复制