Effect of Systemic Inflammatory Response Index on Cardiovascular Disease Risk in Patients with Chronic Kidney Disease

Objective: To investigate the effect of systemic inflammatory response index on cardiovascular disease in patients with chronic kidney disease.Methods: In this prospective cohort study, 12417 patients with chronic kidney disease (CKD) with complete data and no previous history of cardiovascular disease who participated in the health examination for the first time in Kailuan Group from 2006 to 2007 were selected as the observation objects, with new-onset cardiovascular disease as the endpoint event, and followed up until the end of 2021. Patients were grouped according to the SIRI quartile, Kaplan-Meier method was used to calculate the cumulative incidence of cardiovascular diseases and subtypes in different groups, and multivariate Cox proportional risk regression model was used to analyze the impact of different groups on cardiovascular diseases.Result: A total of 12417 participants were included in the study, 75.8% of whom were male. The mean age of the subjects was 57.6±13.5 years. During the mean follow-up period of (11.81±3.84) years, The incidence densities of CVD in each group were 11.79/1000, 13.86/1000, 14.84/1000 and 16.73/1000, respectively. After adjusting for confounding factors such as age and sex, Cox regression analysis showed that compared with group Q1, the HR (95%CI) of CVD in groups Q2, Q3 and Q4 were 1.14 (1.00,1.30), 1.17 (1.03,1.33) and 1.25 (1.10,1.42), respectively, P < 0.05.Conclusion: SIRI is an independent risk factor for cardiovascular disease in patients with chronic kidney disease.