Mechanistic Research and Therapeutic Advances of the JAK/STAT Signaling Pathway in Myocardial Infarction

Myocardial infarction (MI) is a critical heart disease with high incidence and mortality. Current treatments like coronary reperfusion have limitations, including risks of reperfusion injury and bleeding. Understanding MI's molecular mechanisms is vital for developing new strategies. The JAK/STAT pathway plays a key role in MI by regulating inflammation, apoptosis, fibrosis, oxidative stress, and angiogenesis. This article reviews its role in MI pathophysiology and its therapeutic potential, laying a foundation for innovative treatments. As research progresses, modulating JAK/STAT shows promise in reducing myocardial damage and inflammation, offering hope for future effective therapies.翻译搜索复制