Motor phenotypes of amyotrophic lateral sclerosis – a three-determinant anatomical classification based on the region of onset, propagation of motor symptoms, and the degree of upper and lower motor neuron dysfunction
This consensus process aimed to standardize the clinical description of ALS motor phenotypes in clinical practice and research - based on the onset region, propagation pattern, and motor neuron dysfunction. This "OPM classification" contributes to specifying the prognosis, to defining the inclusion or stratification criteria in clinical trials and to correlate phenotypes with the underlying disease mechanisms of ALS.
Authors
- Wolfgang N. Löscher (ORCID: https://orcid.org/0000-0002-7593-3222)
- René Günther (ORCID: https://orcid.org/0000-0003-0329-5644)
- Susanne Petri (ORCID: https://orcid.org/0000-0002-9783-8584)
- Peter Reilich (ORCID: https://orcid.org/0000-0002-2464-0681)
- Patrick Weydt (ORCID: https://orcid.org/0000-0003-2344-5662)
- Sarah Bernsen (ORCID: https://orcid.org/0000-0001-7485-2626)
- Christoph Münch (ORCID: https://orcid.org/0000-0001-9603-0623)
- Paul Lingor (ORCID: https://orcid.org/0000-0001-9362-7096)
- Thomas Meyer (ORCID: https://orcid.org/0000-0002-2736-7350)
- Jochen Hans Weishaupt (ORCID: https://orcid.org/0000-0002-3399-9784)
- Matthias Boentert (ORCID: https://orcid.org/0000-0001-6133-1397)
- André Maier (ORCID: https://orcid.org/0000-0003-2473-4116)
- Torsten Grehl (ORCID: https://orcid.org/0000-0002-0631-6976)
- Ute Weyen
- Julian Großkreutz (ORCID: https://orcid.org/0000-0001-9525-1424)
- Robert Steinbach
- Markus Weber
- Annekathrin Rödiger
- Albert C. Ludolph
- Joachim Wolf
Institutions
- Innsbruck Medical University (AT)
- Universität Ulm (DE)
- German Center for Neurodegenerative Diseases (DE)
- TUM Klinikum (DE)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- BST Bio Sensor Technology (Germany) (DE)
- University Hospital Münster (DE)
- Jena University Hospital (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- DIAKO (DE)
- Alfried Krupp Hospital (DE)
- University Hospital Carl Gustav Carus (DE)
- Ostschweizer Kinderspital (CH)
- Technical University of Munich (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Neurological Research and Practice
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1186/s42466-025-00389-w
- Citations
- 8
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- Charité – Universitätsmedizin Berlin