Factors and causes of cervical cancer (literature review)

The article discusses the factors of cervical cancer. Of course, the main role belongs to the human papillomavirus of high carcinogenic risk. However, there is evidence from the authors that 5-7 % of cervical cancer is HPV-negative. In this regard, the review presents non-viral co-factors of the occurrence of cervical cancer. These factors include: the state of the microbiota of the vaginal biotope, the functions of the resident vaginal microflora, and the state of local vaginal immunity. It has been shown that changes in the quantitative composition of the vaginal microbiota occur in cervical cancer, and dysplastic processes are preceded by chronic inflammation and dysregulation of the immune response.