Preclinical stage of testing new wound dressings in an animal experiment: dynamics of wound healing and the levels of growth factors

Treatment of patients with trophic disorders due to diabetes mellitus is an important medical and social problem, since decompensation and progression of the disease and its complications often lead to disability of patients. The presence of long-term non-healing trophic ulcers requires daily, often painful, dressings, which significantly reduces the quality of life of patients. Therefore, the development of composite hydrogel coatings of prolonged action will solve one of the most important problems of modern surgery. The article presents the results of a biochemical analysis of the blood of laboratory rats with the determination of the level of fibroblast growth factor-2 and endothelin-1 in dynamics against the background of the use of the developed hydrogel wound coatings of prolonged action. Based on the obtained data, the optimal composition of wound dressing for the treatment of trophic ulcers against the background of ischemia in diabetes mellitus was determined.