Mutant p53 Gain of Function: Why Many See It, Why Some Do Not
Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients' tumors. These missense mutant proteins often exhibit pro-oncogenic activities (referred to as gain of function) in mouse models and human cell lines and correlate with poor cancer prognosis in some cases.
Authors
- Kanaga Sabapathy (ORCID: https://orcid.org/0000-0002-4346-7386)
- Guillermina Lozano (ORCID: https://orcid.org/0000-0001-8985-4886)
- Carol Prives (ORCID: https://orcid.org/0000-0003-1846-5562)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Nanyang Technological University (SG)
- Columbia University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1638
- Citations
- 9
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 9.41
Funders
- National Cancer Institute