An Association of IL-6 and TNF Alpha Levels with Hashimoto Thyroiditis in Najaf Province/ Iraq

Background: Cytokines are important in autoimmune thyroid disease. Interleukins regulate immunity. Lack impairs immunity or causes autoimmune disorders. This study is aiming to investigate whether inflammatory cytokines (IL-6, TNF-α) levels in the blood correlate with Hashimoto thyroiditis.Methods: In this study, we used an ELISA device to determine the levels of interleukins in the serum of 60 patients with Hashimoto's disease and 60 people as a control group. We diagnosed the patients based on their clinical condition and also examined their thyroid function and antibodies.Results: According to the research findings, individuals with Hashimoto's thyroiditis had considerably higher levels of IL6 and TNF-α (P < 0.001) and could be used to tell the difference between HT patients and healthy people in the AUC analysis. A positive correlation between (antiTPO, antiTG, TSH) levels and (IL6, TNF-α) levels has also been demonstrated, which may indicate that these changes play a role in the development of HT.Conclusions: This study clearly established that the levels of IL6, TNF alpha is strongly related with the risk of HT in individuals in Najaf Province, Iraq