The Association of Single Nucleotide Polymorphism (+1893CC/AA) of INPPL1 Gene with Type 2 Diabetes Mellitus in AL-Najaf Population

Background: Insulin resistance in the insulin target tissue and insufficient insulin production by pancreatic β-cells are the hallmarks of chronic type 2 diabetes mellitus (T2DM). Certain INPPL1 gene variants have been associated with type 2 diabetes in Indian, Japanese, British, and French populations, according to researches.Objectives: Evaluate the relationship between the risk of type 2 diabetes mellitus (T2DM) in the AL-Najaf community and single nucleotide polymorphisms (SNPs) in the INPPL1 gene. Methods: A case-control research was conducted with a sample size of 200 individuals. The INPPL1 gene's single nucleotide polymorphism (+1893CC/AA) was genotyped using the PCR-RFLP technique. Results: The frequency of the A allele (p < 0.001) was shown to be considerably greater in T2DM patients, and SNP +1893CC/AA was found to be strongly linked with T2DM. Conclusion: The vulnerability of the AL-Najaf community to type 2 diabetes mellitus has been strongly connected to the single nucleotide polymorphism (+1893CC/AA) in the INPPL1 gene, according to the results.