Effects of Multivitamin Supplementation on Liver Enzymes in Depressive Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial and Community Health Implications

Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition commonly observed in depressive patients.Objective: this randomized clinical trial aimed to investigate the effects of multivitamin supplementation on liver enzymes in depressive patients with NAFLD. Methods: The study randomly divided the participants into two groups: the intervention group, which received multivitamin supplementation, and the control group, which received a placebo. The researchers examined liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and serum bilirubin to evaluate liver function. They conducted statistical analyses to compare the changes in the levels of these liver enzymes between the two groups.Results: The results demonstrated that the multivitamin supplementation group showed a statistically significant decrease in ALT, AST, ALP and serum bilirubin levels compared to theplacebo group. Also results showed that the multivitamin supplementation group exhibited significant improvements in depressive symptom scores compared to the placebo group.Conclusion: The results of this study indicate that multivitamin supplementation could potentially improve liver function in individuals with non-alcoholic fatty liver disease (NAFLD) who also suffer from depression. However, additional research is needed to investigate the underlying mechanisms and long-term impacts of multivitamin supplementation on liver health specifically in this group of patients.