The Effect of Sterol Regulatory Element-Binding Protein-1 C Modification on Fatty Acids in Alcoholic Liver Disease (ALD)

Abstract : Among chronic liver diseases, alcoholic liver disease (ALD) is the most common in the world. The main cause of ALD is excessive alcohol consumption. The accumulation of fatty acids in liver cells is one of the oldest and most famous alcohol-related changes that cause the development of ALD . Although the mechanism by which excessive alcohol intake leads to fatty acid accumulation is far-fetched and complex, one of the mechanisms by which alcohol affects fatty acids is the regulation of the sterol regulatory element-binding protein-1 c (SREBP-1 C) which may be key to the treatment of ALD. In this review, we present evidence supporting the key important role of the SREBP-1 C in influencing the synthesis and accumulation of fatty acids that are a major cause of ALD, and we suggest that there should be future studies to evaluate the modification of the SREBP-1 C as a possible new treatment for alcoholic liver disease.