Synthesis and Evaluation of the Biological Activity of Heterocyclic Derivatives Containing the 1,3,4 Thiadiazole Ring

In this article: A series of new heterocyclic molecules with five and six members were prepared from 1,3,4-thiadiazole derivative with a terminal primary amine group and was used to synthesize a Schiff base (6) by interaction with 5-chloro salicylaldehyde and using ethanol as a solvent. After that, it was able to prepare numerous chemical compounds utilizing the Schiff base. Which contains a C=N group with (2-aminobenzoic acid, 2-mercaptobenzoic acid, valine, alanine, and sodium azide) to prepare hydroqinazoline (6a), thiazinone derivative (6b), and imidazolidine derivatives, (6c,6d). TLC follows these reactions and Melting points for derivatives were measured. These compounds were determined by 13C-NMR, 1H-NMR, and FT-IR spectra, along with studying the biological activity of the prepared derivatives.