Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing <i>NRAS</i> -Mutant Melanoma to MEK Inhibitors
Nitrosylation-regulated molecular mechanisms present a vulnerability that can be exploited to sensitize NRAS-mutant melanomas to existing targeted therapies while enhancing antitumor immunity.
Authors
- Álvaro de Mingo Pulido (ORCID: https://orcid.org/0000-0001-9814-1837)
- John M. Koomen (ORCID: https://orcid.org/0000-0002-3818-1762)
- Sanjay Premi (ORCID: https://orcid.org/0000-0002-5492-5469)
- Ruth Halaban (ORCID: https://orcid.org/0000-0001-8451-1964)
- Paulo C. Rodrı́guez (ORCID: https://orcid.org/0000-0001-7480-6566)
- Montana M. Young (ORCID: https://orcid.org/0009-0009-6379-0752)
- Kenneth Yee Tsai (ORCID: https://orcid.org/0000-0001-5325-212X)
- Vipin Yadav (ORCID: https://orcid.org/0000-0001-9862-5233)
- Nitin Inamdar (ORCID: https://orcid.org/0009-0006-3964-7364)
- Keiran S.M. Smalley (ORCID: https://orcid.org/0000-0003-1089-9307)
- Rachel V. Jimenez (ORCID: https://orcid.org/0000-0003-2510-2268)
- Bin Fang (ORCID: https://orcid.org/0000-0002-7636-1318)
- Jyoti Srivastava (ORCID: https://orcid.org/0000-0002-3146-9317)
- Pravin R. Phadatare (ORCID: https://orcid.org/0009-0009-8310-6225)
- Antonella Bacchiocchi
Institutions
- Vanderbilt University (US)
- Moffitt Cancer Center (US)
- Yale University (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1158/0008-5472.can-24-0693
- Citations
- 9
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.18
Funders
- Moffitt Cancer Center
- National Institutes of Health
- University of Texas MD Anderson Cancer Center