HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine
Cervical cancer is the fourth leading cause of cancer deaths in women worldwide. Although the disease is driven by two antigenic viral oncoproteins, therapeutic vaccines have proved ineffective, inferentially due to systemic immunosuppression. This study elucidated an actionable mechanism, whose disruption renders an oncoprotein vaccine efficacious, with translational potential.
Authors
- Elin Jaensson Gyllenbäck (ORCID: https://orcid.org/0000-0002-1334-8642)
- Douglas Hanahan (ORCID: https://orcid.org/0000-0002-0883-5251)
- Morgane Lecointre
- Rachel Marcone (ORCID: https://orcid.org/0000-0002-5711-8435)
- Krisztián Homicskó (ORCID: https://orcid.org/0000-0003-0912-6198)
- Nadine Fournier (ORCID: https://orcid.org/0000-0002-9347-7929)
- Jérémy Guillot (ORCID: https://orcid.org/0000-0002-2748-5728)
- David Liberg (ORCID: https://orcid.org/0009-0009-0645-746X)
- Dilara Ozdoganlar
- Marjorie Cayatte
Institutions
- SIB Swiss Institute of Bioinformatics (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Obducat (Sweden) (SE)
- Hôpital Orthopédique de la Suisse Romande (CH)
- Ludwig Cancer Research (CH)
- Swiss Cancer Center Léman (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0382
- Citations
- 5
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Ludwig Institute for Cancer Research
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- European Research Council