Exploring STEAP1 Expression in Prostate Cancer Cells in Response to Androgen Deprivation and in Small Extracellular Vesicles
Understanding how androgen dependence affects STEAP1 expression in both tumor cells and sEVs across distinct disease stages will illuminate the clinical benefit of combinatorial AR and STEAP1-directed therapies and inform the optimal placement of STEAP1 targeting within the prostate cancer disease continuum.
Authors
- Ishan Chaudhari
- David W. Goodrich (ORCID: https://orcid.org/0000-0002-1021-1827)
- Cecilia E. Verrillo (ORCID: https://orcid.org/0000-0003-0180-7554)
- Camila A. Bach (ORCID: https://orcid.org/0000-0002-4630-358X)
- Alessandro Fatatis (ORCID: https://orcid.org/0000-0003-3945-8513)
- Waleed Iqbal (ORCID: https://orcid.org/0000-0002-1478-2969)
- Gabriel A. Rabinovich (ORCID: https://orcid.org/0000-0002-0947-8735)
- Ricardo A. Santos
- Kevin Zarrabi (ORCID: https://orcid.org/0000-0002-9351-2317)
- William K. Kelly (ORCID: https://orcid.org/0000-0003-2629-672X)
- Candice L. Bizzaro
- Ada G. Blidner (ORCID: https://orcid.org/0000-0002-1092-3656)
- Matthew J. Schiewer (ORCID: https://orcid.org/0000-0002-2325-4228)
- Nicole M. Naranjo (ORCID: https://orcid.org/0000-0002-0988-2930)
- Justine J. Jacobi (ORCID: https://orcid.org/0000-0002-9109-3294)
- Lucia R. Languino (ORCID: https://orcid.org/0000-0001-9011-7031)
- Francis J. Picone
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Thomas Jefferson University (US)
- Sidney Kimmel Cancer Center (US)
- Exact Sciences (United States) (US)
- National Research Council (LK)
- Fundación Ciencias Exactas y Naturales (AR)
- Drexel University (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-0903
- Citations
- 4
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- U.S. Department of Defense
- Thomas Jefferson University
- National Institutes of Health
- National Cancer Institute