Nonoperative Management of Mismatch Repair–Deficient Tumors
Among patients with early-stage dMMR solid tumors that were amenable to curative-intent surgery, neoadjuvant PD-1 blockade led to organ preservation in a high proportion of patients. (Funded by Swim Across America and others; ClinicalTrials.gov number, NCT04165772.).
Authors
- Martin Weiser (ORCID: https://orcid.org/0000-0002-1071-0044)
- Emmanouil Pappou
- Daniela Molena (ORCID: https://orcid.org/0000-0003-1655-4473)
- Oliver Artz (ORCID: https://orcid.org/0000-0002-5708-1281)
- Imane El Dika (ORCID: https://orcid.org/0000-0003-0067-4198)
- Benoı̂t Rousseau (ORCID: https://orcid.org/0000-0002-1594-4827)
- Yelena Y. Janjigian (ORCID: https://orcid.org/0000-0002-5357-5858)
- Melissa Lumish (ORCID: https://orcid.org/0000-0003-4173-5567)
- Maria Widmar (ORCID: https://orcid.org/0000-0002-1145-8370)
- Jill Weiss
- Callahan M. Wilde (ORCID: https://orcid.org/0000-0002-3700-1387)
- Andrea Cercek (ORCID: https://orcid.org/0000-0002-5054-8192)
- Leonard B. Saltz (ORCID: https://orcid.org/0000-0001-8353-4670)
- Vivian E. Strong (ORCID: https://orcid.org/0000-0001-5044-1662)
- Rona Yaeger (ORCID: https://orcid.org/0000-0002-7233-5454)
- Mark Andrew Schattner (ORCID: https://orcid.org/0009-0008-0448-2736)
- Michael B. Foote (ORCID: https://orcid.org/0000-0003-3027-2405)
- Luis Alberto Diaz (ORCID: https://orcid.org/0000-0002-7079-8914)
- Mithat Gönen (ORCID: https://orcid.org/0000-0001-8683-8477)
- Guillem Argilés (ORCID: https://orcid.org/0000-0002-1487-7108)
- Steven B. Maron (ORCID: https://orcid.org/0000-0002-8794-130X)
- Paul Bernard Romesser (ORCID: https://orcid.org/0000-0001-8268-2903)
- Alice Zervoudakis (ORCID: https://orcid.org/0009-0000-4818-7933)
- Marina Shcherba (ORCID: https://orcid.org/0000-0001-9769-9855)
- Kevin C. Soares (ORCID: https://orcid.org/0000-0002-0406-017X)
- J. Joshua Smith (ORCID: https://orcid.org/0000-0003-2538-5456)
- Neil H. Segal (ORCID: https://orcid.org/0000-0002-3047-2303)
- Wassim Abida (ORCID: https://orcid.org/0000-0002-9006-7043)
- Ping Gu
- Gopa Iyer (ORCID: https://orcid.org/0000-0002-5093-6099)
- Mitesh Patel (ORCID: https://orcid.org/0000-0001-6724-9183)
- Ryan Sugarman
- Geoffrey Y. Ku (ORCID: https://orcid.org/0000-0002-0448-1038)
- Marc J. Gollub (ORCID: https://orcid.org/0000-0002-6008-0730)
- Jenna Sinopoli (ORCID: https://orcid.org/0000-0003-0167-2792)
- Iris H. Wei (ORCID: https://orcid.org/0000-0001-9006-9105)
- Santiago Aparo
- Zsofia Kinga Stadler (ORCID: https://orcid.org/0000-0002-6985-2864)
- Avni M. Desai
- Jonathan Coleman (ORCID: https://orcid.org/0000-0002-6428-7835)
- Jinru Shia (ORCID: https://orcid.org/0000-0002-4351-2511)
- Philip B. Paty (ORCID: https://orcid.org/0000-0002-7045-2112)
- Tae-Hyung Kim (ORCID: https://orcid.org/0000-0002-5045-4401)
- Seth Cohen
- Lindsay Temple
- Julio García Aguilar
- G Fumo
- Vetri S. Jayaprakasham
Institutions
- Baptist Hospital of Miami (US)
- Hartford Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Cancer Institute (WIA) (IN)
- University Hospitals Cleveland Medical Center (US)
- Case Comprehensive Cancer Center
- Hartford Financial Services (United States)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1056/nejmoa2404512
- Citations
- 111
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 163.35