Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma
We demonstrate that while integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants do not directly correlate with metastatic behavior. Further, serum ITGA2-UEA appeared as a potential radioresponse biomarker.
Authors
- Heikki Irjala (ORCID: https://orcid.org/0000-0003-3054-4677)
- Randa Mahran (ORCID: https://orcid.org/0000-0001-6529-4378)
- Eero Kytö (ORCID: https://orcid.org/0000-0002-2567-5931)
- Sami Ventelä (ORCID: https://orcid.org/0000-0001-6672-6662)
- Johannes Routila (ORCID: https://orcid.org/0000-0001-5385-7065)
- Seppo Salminen (ORCID: https://orcid.org/0000-0002-9737-7642)
- Kim Pettersson (ORCID: https://orcid.org/0000-0002-3749-5591)
- Janne Leivo (ORCID: https://orcid.org/0000-0002-1032-6667)
- Eeva Haapio (ORCID: https://orcid.org/0000-0002-3349-6829)
- Erica Routila (ORCID: https://orcid.org/0009-0005-5639-3602)
- Kamlesh Gidwani (ORCID: https://orcid.org/0000-0002-9014-0618)
- Mervi Toriseva
Institutions
- Åbo Akademi University (FI)
- University of Turku (FI)
- Turku Centre for Computer Science (FI)
- Turku University Hospital (FI)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1002/cam4.70717
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Suomen Lääketieteen Säätiö
- Korvatautien Tutkimussäätiö
- Academy of Finland
- Turun Yliopistosäätiö