STIMULATING EFFECT OF TRANSCRANIAL ELECTRICAL EXPOSURE ON REPARATIVE PROCESSES IN AN EXPERIMENT

Electrical stimulation with analgesic current parameters is considered a promising method for developing effective and non-invasive pain relief and therapy methods due to its easily controllable and rapid pain relief, and the absence of side effects, toxic, and allergic complications. Purpose: to study the effect of transcranial electrical stimulation of the brain’s antinociceptive system on the healing process of skin wounds in laboratory animals. Materials and methods. The study involved 80 male non-linear white laboratory rats. The first experimental group used a mode of transcranial electrical stimulation combining direct and alternating currents with analgesic parameters. The second and third experimental groups used the same combination but with different pulse frequencies, i.e. 50 and 90 Hz (“non-analgesic irritation” frequencies). Sessions were conducted once a day for 30 minutes for three days after skin wounds were inflicted. Additionally, experiments were conducted with two modes of exposure: for three days before the wound infliction and three days after the operation (i.e. “preventive” and “therapeutic” effects), using both analgesic and non-analgesic modes of electrical exposure. Results. Under the influence of transcranial electrical stimulation with analgesic current parameters (70 Hz frequency), a significant acceleration by 21% of the healing process and a reduction in the average time for complete wound healing were observed. Transcranial exposures with “non-analgesic irritation frequencies” (50 and 90 Hz) did not cause any changes in the healing rate compared to the control. The greatest acceleration of wound healing under the influence of therapeutic procedures was significantly manifested on the 4th – 7th day after their infliction, while in the control group, it was on the 10th – 11th day. In the “preventive” group, the change in wound size significantly outpaced that of rats with “therapeutic” exposure: on the 4th day, the difference in wound area between the experimental groups and the control was statistically significant and amounted to 12%, while the “therapeutic” exposure reached a similar result by the 8th day. Conclusion. Information was obtained on the effect of electric current on brain electrical activity, behavioral reactions, and reparative processes. EDN: UUVZTP