THERAPEUTIC AND PREVENTIVE MEASURES FOR KETOSIS OF COWS

The study examined the effect of the drug Catozal 10% on the body of highly productive cows. Ketosis in dairy cows is a metabolic disease that is widespread among high-producing cows. The search for means to reduce the risk of this pathology and drugs for its prevention remains relevant. The purpose of the work is to develop and conduct experimental testing of a scheme of treatment and preventive measures for ketosis using the administration of the immunomodulating drug Catozal 10% and to evaluate its effectiveness in normalizing the metabolic processes of the body of cows. We used 2 groups of black-and-white Holstein cows of 5 heads each with a milk yield for the previous lactation of 8000-9000 kg and above-average fatness (from 4 to 5 points). The following scheme for the prevention of ketosis was developed: the experimental group (I) was administered the drug Catozal 10% three times: 7 days before the expected calving and on the 1st and 2nd days after calving, intramuscularly at a dose of 10 ml per head. The control group (II) of cows was fed propylene glycol at a dose of 100 ml/head. 2 times a day for 10 days after calving. Biochemical blood parameters were examined on the 5th day after calving, the level of total protein, glucose, reserve alkalinity, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and alkaline phosphatase were determined. On days 3 and 14, the level of ketone bodies in the blood was determined. Physicochemical indicators were determined in milk on the 14th day after calving: density, fat, protein and lactose content. The alkaline phosphatase level in both groups was significantly increased, which may indicate liver damage. This is also indicated by increased AST values ​​in animals. An increase in LDH levels is a marker for the development of ketosis. This indicator is quite high in animals of both groups, but in animals of the second group it is significantly higher by 16% and goes beyond the physiological norm. In general, animals in the control group had a more unstable biochemical blood picture, characteristic of ketogenesis in cows. The average daily milk yield in the first group was 28.44 kg, which is 1.28 kg more than that of the control group. When converted to base fat content (3.4%), this difference amounted to 2.25 kg on average for the group. Thus, the high effectiveness of the developed scheme for the prevention of ketosis using the drug Catozal 10%, confirmed by clinical, biochemical and planimetric studies, has been established. Enterprises can be recommended to use the specified scheme for the prevention of ketosis. EDN: AQQGRC