Formulation and Evaluation of Sustained Release Matrix Tablet of Quinapril by Using Natural Polymers

Abstract: In present investigation an attempt has been made to design and develop some Quinapril matrix tablets using KarayaGum, Guar gum, KollidonSRas release retarding polymers. Quinapril is Anti-hypertensive drug which lowers blood pressure level and has been selected to prepare sustained release dosage forms. Quinapril sustained release matrix tablets were prepared using KarayaGum, Guar gum, KollidonSR as base polymer by wet granulation method. FTIR spectral analysis showed that characteristic peak of Quinapril pure drug was retained in the spectra of all the formulations indicating the intactness of the drug in all the formulations. Quinapril matrix tablets formulated employing Kollidon SR and combination of Karaya Gum and Guar gum provided slow and controlled release of Quinapril up to 24 hr. All the tablet formulation showed compliance with pharmacopoeia standard as the time increases. The dissolution result shows that an increased amount of polymer resulted in reduced drug release. A concentration dependent drug release is evident in case of the polymer i.e., lower concentration of polymers, release is marginally retarded at higher concentration is considerable. Prepared sustained formulation containing KarayaGum, Guar gum, KollidonSR as release retarding polymers (F6) probably showing better release based up to 98% drug release within 24 hours.