Mitochondrial complex I deficiency occurs in skeletal muscle of a subgroup of individuals with Parkinson’s disease
Our findings support the existence of a PD subpopulation characterized by CI pathology in skeletal muscle and suggest that stratification by extra-neural mitochondrial dysfunction may be informative for selecting individuals for clinical trials.
Authors
- Charalampos Tzoulis (ORCID: https://orcid.org/0000-0003-0341-5191)
- Ragnhild Eide Skogseth (ORCID: https://orcid.org/0000-0001-6688-9955)
- Irene H. Flønes (ORCID: https://orcid.org/0000-0001-9612-0696)
- Gonzalo S. Nido (ORCID: https://orcid.org/0000-0002-1766-4108)
- Kjersti Eline Stige (ORCID: https://orcid.org/0000-0003-4522-1117)
- Haakon Berven (ORCID: https://orcid.org/0009-0001-2996-9590)
- Christian Dölle (ORCID: https://orcid.org/0000-0003-2427-8130)
- Erika Fernández‐Vizarra (ORCID: https://orcid.org/0000-0002-2469-142X)
- Brage Brakedal (ORCID: https://orcid.org/0000-0002-4081-0871)
- Katarina Lundervold (ORCID: https://orcid.org/0009-0006-6814-9460)
- Yamila N. Torres Cleuren (ORCID: https://orcid.org/0000-0003-2218-7243)
- Kristoffer Haugarvoll (ORCID: https://orcid.org/0000-0001-9381-1109)
- Michele Brischigliaro (ORCID: https://orcid.org/0000-0003-1520-1342)
- Sepideh Mostafavi (ORCID: https://orcid.org/0000-0002-4652-5203)
- Simon Ulvenes Kverneng (ORCID: https://orcid.org/0000-0002-8507-8127)
- Geir Olve Skeie (ORCID: https://orcid.org/0000-0001-5527-5739)
- Lilah Toker (ORCID: https://orcid.org/0000-0002-6514-561X)
Institutions
- University of Padua (IT)
- Norwegian University of Science and Technology (NO)
- Haukeland University Hospital (NO)
- Veneto Institute of Molecular Medicine (IT)
- St Olav's University Hospital (NO)
- Haraldsplass Diakonale Sykehus (NO)
- University of Bergen (NO)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-04-27
- DOI
- https://doi.org/10.1038/s43856-025-00817-7
- Citations
- 4
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Stiftelsen Kristian Gerhard Jebsen
- Helse Vest
- Universitetet i Bergen
- Norges Forskningsråd
- Haukeland Universitetssjukehus