Role of Cancer Stem Cells in Failure of T Cell Immunotherapy

Over the past decade, immunotherapy has emerged as one of the most promising approaches to cancer treatment. Immunotherapy employing Immune-Checkpoint Inhibitors (ICIs), Adoptive Cell Transfer (ACT), Chimeric Antigen Receptor (CAR) engineered T cells and cancer vaccines, have generated encouraging responses in the treatment of various cancers, and effector anti tumor T cells are observed as major component in these measures.