Neutrophils to lymphocytes, platelets to lymphocyte and neutrophil to eosinophil ratios as predictors of breast cancer disease: correlation with superoxide dismutase activities

The histopathological classification of breast carcinoma (BC) is based on the diversity of the morphological features of the tumors.70%–80% of BC patients belongs to invasive ductal carcinomas (IDCs) or invasive lobular carcinoma (ILC). Luminal A, Luminal B, HER2 +, and Triple Negative are molecular subtypes. NLR, PLR, and NER are inflammatory ratios. Superoxide dismutase (SOD) is antioxidant. The aim: is to study the role of latter ratios and enzyme activity in BC patients. Patients and methods: blood sample were withdrawn from BC patients (n=90) and from the healthy control (n=15). Complete blood picture was done and ratios were calculated. Also, SOD activity was assayed. Results: The mean of NLR and PLR were significantly increased in the blood of the BC patients when compared with those of healthy control (P=0.001). At cutoff value >1.59 and >102.59, ROC curve had the ability to differentiate the patients from healthy control (AUC=0.87 and 0.9, P<0.0001). The mean of NER and SOD activity were significantly decreased when compared with those of healthy control (P<0.0001). The Roc curve at cutoff value of ≤69.7 and ≤ 167.4 can significantly differentiate BC patients from the healthy control with AUC values of 0.84 and 1.0, respectively. The molecular subtypes also showed the same patterns of the later classifications. Conclusion: The increment in NLR, PLR and the decrement in both SOD activity and NER confirm the inflammatory picture of BC, and can be used for its assessment.